Chemistry @ Colgate

John Cochran

Research Projects Description

For the past few years we have been interested in the synthesis, characterization and bioactivity of a series of compounds containing both a trisubstituted tin functional group and a dithiocarbamate functional group.  The compounds we are making have carbon spacers separating the tin and sulfur groups:

R3Sn(CH2)n SC(S)NEt2

R = Me, Bu, Ph
n = 4, 6

We have also used a cyclohexane ring as a spacer.  The synthetic chemistry has led us to a study of the conformational equilibria of cis- and trans- 1, 4-bromochlorocylohexane.


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