Roger S. Rowlett
Professor of Chemistry
Chair of the Department
B.S. (Biochemistry) 1976, University of Alabama
Ph.D. (Chemistry) 1981, University of Alabama
Teaching Interests: Biochemistry, Analytical
Chemistry, General Chemistry
Research Interests: Enzymology, the isolation,
purification, and characterization of enzymes, especially
experimental kinetics; Protein Engineering, the specific
alteration of enzyme structure using recombinant DNA methods; X-ray
Crystallography, the determination of three-dimensional protein structures
from X-ray diffraction by single protein crystals.
Detailed descriptions of current
research projects are available.
- Daniel Clark, Roger S. Rowlett, John R. Coleman, and Daniel F. Klessig,
"Complementation of the yeast deletion mutant ΔNCE103
by members of the β class of carbonic
anhydrases is dependent on carbonic anhydrase activity rather than on
antioxidant activity," Biochem. J. 2004, 379, 609-615.
- Roger S. Rowlett, Chingkuang Tu, Paul S. Murray,* and Joy E. Chamberlin,*
"Examination of the role of Gln-158 in the Mechanism of CO2
Hydration Catalyzed by b-Carbonic Anhydrase
from Arabidopsis thaliana," Arch. Biochem. Biophys., 2004,
S. Rowlett, “Elements of a Competitive NIH-AREA proposal,” Council on Undergraduate
Research Quarterly 2004, 24, 120-124.
- Chingkuang Tu, Roger S. Rowlett, Brian C. Tripp, James G. Ferry, and
David N. Silverman, "Chemical Rescue of Proton Transfer in Catalysis
by Carbonic Anhydrases in the b- and g-Class,"
Biochemistry 2002, 41,
- Roger S. Rowlett, Chingkuang Tu, Melissa
M. McKay,* Jeffrey R. Preiss,* Rebecca J. Loomis,* Katherine
A. Hicks,* Robb J. Marchione,* Jacob A. Strong,* George S.
Donovan, Jr.,* and Joy E. Chamberlin,*
"Kinetic Characterization of Wild-Type and Proton Transfer-Impaired
Variants of β-Carbonic Anhydrase from Arabidopsis thaliana," Arch. Biochem. Biophys.
2002, 404, 197-209.
- Kwang-Hwan Jhee, Li-Hong Yang, S. Ashraf Ahmed, Peter
McPhie, Roger Rowlett, and Edith Wilson Miles,
"Mutation of an Active Site Residue of Tryptophan
Synthase (bS377) Alters
Cofactor Chemistry," J. Biol. Chem. 1998,
- C. Larry Bering, Jennifer S. Kuhns, and Roger S. Rowlett,
"Purification of Bovine Carbonic Anhydrase by
Affinity Chromatography: An Undergraduate Biochemistry
Laboratory Experiment," J. Chem. Ed. 1998,
- Roger Rowlett, Lihong Yang, S. Ashraf
Ahmed, Peter McPhie, Kwang-Hwan Jhee, and Edith W. Miles,
"Mutations in the Contact Region between the a and b Subunits
of Tryptophan Synthase alter Subunit Interaction and
Intersubunit Communication," Biochemistry
1998, 37, 2961-2968.
- Roger S. Rowlett, Mark R. Chance, Michael D. Wirt, Dean
E. Sidelinger, Jill R. Royal,* Melanie Woodroffe,*
Ying-Fuh A. Wang,* Rajib P. Saha,* and Michael G. Lam*,
"Kinetic and Structural Characterization of Spinach
Carbonic Anhydrase," Biochemistry 1994,
Asterisks indicate undergraduate student co-authors who
conducted their research in collaboration with a faculty member
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